Griseofulvin: Side effects, dosage, uses, and more

Griseofulvin oral tablet is available as both a generic and brand-name drug. Brand name: Gris-PEG.
Griseofulvin also comes as a liquid suspension you take by mouth.
Griseofulvin oral tablet is used to treat fungal infections of your hair, nails, and skin.

Serious skin reactions warning: This drug can cause skin reactions. These may be serious and life threatening. Symptoms can include hives, fever, swelling of your tongue and face, and peeling or blistering of your skin. If you have signs of a skin reaction, stop taking the drug and call your doctor right away.
Liver damage warning: This drug can cause serious liver damage. This effect is more likely if you use the drug at high doses or for long periods of time. Symptoms can include bruising that happens easily, tiredness, weakness, stomach pain, lack of appetite, and yellowing of your skin or the whites of your eyes.
Pregnancy warning: You should not take this drug if you are pregnant or planning to become pregnant. This drug may make hormonal birth control less effective at preventing pregnancy. You should use a method of birth control that uses no hormones (diaphragms, condoms, copper IUD) during treatment with this drug. If you become pregnant, stop taking griseofulvin right away and talk with your doctor. Men should also use birth control during treatment and for 6 months after stopping treatment with this drug.

Griseofulvin oral tablet is a prescription drug that's available as the brand name drug Gris-PEG. It's also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Griseofulvin also comes as an oral liquid suspension.

Why it's used

Griseofulvin oral tablet is used to treat fungal infections that can affect different parts of your body. These include your hair, nails, and skin.

How it works

Griseofulvin belongs to a class of drugs called antifungal agents. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This drug works by binding to a part of the fungus causing the infection in your body. This stops the fungus from multiplying. This drug also prevents fungus from spreading to new cells. These actions cause the infection to die off.

Griseofulvin oral tablet doesn't cause drowsiness. However, it can cause other side effects.

More common side effects

The more common side effects of griseofulvin can include:

rash
numbness or tingling in your hands or feet
yeast infections in your mouth
stomach pain
diarrhea
heartburn
nausea
vomiting
dizziness
headache
trouble sleeping
confusion

If these side effects are mild, they may go away within a few days or a couple of weeks. If they're more severe or don't go away, talk with your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you're having a medical emergency. Serious side effects and their symptoms can include the following:

Severe skin allergic reaction. Symptoms can include:
- swelling of your face or tongue
- hives
- skin blisters or peeling
- fever
Liver damage. Symptoms can include:
- bruising more easily than normal
- tiredness
- weakness
- stomach pain
- loss of appetite
- yellowing of your skin or the whites of your eyes

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare professional who knows your medical history.

Griseofulvin oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you're taking. To find out how griseofulvin oral tablet might interact with something else you're taking, talk with your doctor or pharmacist.

Interactions that can make your drugs less effective

When certain drugs are used with griseofulvin, these other drugs may not work as well. This is because the amount of these drugs in your body may be decreased. Examples of these drugs include:

Warfarin: Your doctor may increase your dosage of warfarin while you're taking griseofulvin.
Birth control pills: Your doctor may have you use a second form of birth control that works better. You should not get pregnant during your treatment with this drug.
Cyclosporine: Your doctor may increase your dosage of cyclosporine while you're taking griseofulvin.
Salicylates such as aspirin and magnesium salicylate

When you take griseofulvin with certain drugs, griseofulvin may not work as well to treat your condition. This is because the amount of griseofulvin in your body may be decreased. Examples of these drugs include:

Barbiturates such as phenobarbital and butabarbital: Your doctor may increase your dosage of griseofulvin.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Griseofulvin oral tablet comes with several warnings.

Allergy warning

Griseofulvin can cause a severe allergic reaction. Symptoms can include:

trouble breathing
swelling of your throat or tongue

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Don't take this drug again if you've ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interaction

This drug may make you more sensitive to the effects of alcohol. You should not drink alcohol while you're taking this drug. If you drink alcohol, talk with your doctor.

Warnings for people with certain health conditions

For people with porphyria (a genetic blood disease): You should not take this drug. It can make your condition worse.

For people with liver problems: This drug can make your condition worse. If you have liver failure, you should not take this drug. If you're taking other drugs that can cause liver issues, you're at increased risk of liver problems from this drug. Ask your doctor if this drug is safe for you.

For people with lupus: This drug may make your condition worse. Ask your doctor if this drug is safe for you.

Warnings for other groups

For pregnant women: Griseofulvin is a category X pregnancy drug. Category X drugs should never be used during pregnancy. Women who are pregnant should not take any form of griseofulvin.

Call your doctor right away if you or your partner become pregnant while taking this drug.

Men should use reliable birth control during treatment and for 6 months after stopping treatment with this drug. Women of childbearing age should use reliable birth control throughout treatment with this drug.

For women who are breastfeeding: Griseofulvin may pass into breast milk and cause side effects in a child who is breastfed. Talk with your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For children: This drug has not been established as safe and effective in children 2 years of age and younger. In addition, safety has not been established in children older than 2 years of age at dosages greater than 10 mg/kg daily.

This dosage information is for griseofulvin oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

your age
the condition being treated
how severe your condition is
other medical conditions you have
how you react to the first dose

Forms and strengths

Generic: Griseofulvin

Form: Oral tablet (ultramicrosize)
Strengths: 125 mg, 250 mg

Form: Oral tablet (microsize)
Strengths: 250 mg, 500 mg

Brand: Gris-PEG

Form: Oral tablet (ultramicrosize)
Strengths: 125 mg, 250 mg

Dosage for fungal infections

Adult dosage (ages 18 years and older)

Ultramicrosize:
- Typical starting dosage: 375 mg in one dose or in divided doses. This dosage is common for infections that are not too severe. These include infections of your scalp, hair, and body.
- Dosage adjustments: If you have an infection that is harder to treat, such as a foot or nail infection, your doctor may tell you to take 750 mg per day in divided doses.
- Length of treatment: 2 weeks to more than 6 months. The length of your treatment depends on how severe your infection is and where it's located.
Microsize:
- Typical starting dosage: 500 mg in one dose or in divided doses. This dosage is common for infections that are not too severe.
- Dosage adjustments: If you have an infection that is harder to treat, your doctor may give you 750–1000 mg per day in divided doses. Your doctor may slowly decrease your dosage as your infection clears.
- Length of treatment: 2 weeks to more than 6 months. The length of your treatment depends on how severe your infection is and where it's located.

Child dosage (ages 3–17 years)

Ultramicrosize
- Typical dosage: 3.3 mg/lb. of body weight per day
  - For children who weigh 35–60 lbs.: 125–187.5 mg per day
  - For children who weigh more than 60 lbs.: 187.5–375 mg per day
  - Children with an infection on their scalp may only need one dose to treat their infection.
- Length of treatment: 2 weeks to more than 6 months. The length of your child's treatment depends on how severe the infection is and where it's located.
Microsize
- Typical dosage: 10 mg/kg of body weight per day
  - For children who weigh 30–50 lbs: 125–250 mg per day
  - For children who weigh more than 50 lbs: 250–500 mg per day
- Length of treatment: 2 weeks to more than 6 months. The length of your child's treatment depends on how severe the infection is and where it's located.

Child dosage (ages 0–1 years)

This medication has not been studied in children younger than 2 years. It should not be used in people younger than 2 years.

Warnings

If you take a higher dosage of this drug or use it for a long time, you may have a higher risk of more severe side effects. These can include skin reactions and liver problems.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Griseofulvin oral tablet is used for short-term treatment. It comes with risks if you don't take it as prescribed.

If you stop taking the drug suddenly or don't take it at all: Your infection will continue to grow. It may also spread to other parts of your body.

If you miss doses or don't take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. This can increase your risk of side effects. These side effects could become serious.

If you think you've taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. If you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: The symptoms of your infection should clear up.

Keep these considerations in mind if your doctor prescribes griseofulvin oral tablet.

General

Take this drug with milk or a fatty food, such as peanut butter or ice cream. This will help your body absorb the drug better. It will also reduce stomach upset.
You can cut or crush the tablet.
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Storage

Store griseofulvin oral tablets at room temperature between 59°F and 86°F (15°C and 30°C).
Keep this drug away from light.
Don't store the tablets in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
Don't worry about airport X-ray machines. They can't hurt your medication.
You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
Don't put this medication in your car's glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

Your doctor should monitor certain health issues while you take this drug. This helps make sure you stay safe during your treatment. These issues include:

Kidney function. Your doctor will do blood tests to check your kidney function. If your kidneys aren't working well, your doctor may reduce your dosage or stop your treatment with this drug.
Liver function. Your doctor will do blood tests to check your liver function. If your liver isn't working well, your doctor may stop your treatment with this drug,
Blood cell levels. Your doctor will check your red blood cell and white blood cell counts during your treatment. If these tests show that you're having side effects, your doctor may stop your treatment with this drug.

Sun sensitivity

This drug can make your skin more sensitive to the sun. This effect increases your risk of sunburn. Avoid the sun if you can. If you can't, be sure to wear protective clothing and sunscreen.

Insurance

Some insurance companies require a prior authorization for this drug. This means your doctor may need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk with your doctor about other drug options that may work for you.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Threadworm Medicine