Janumet and Janumet XR: Side effects, dosage, price, and more - Medical News Today
Janumet and Janumet XR can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Janumet or Janumet XR. These lists do not include all possible side effects.
For more information about the possible side effects of Janumet or Janumet XR, talk with your doctor or pharmacist. They can give you tips on managing any side effects that may be concerning or bothersome.
Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you've had with Janumet or Janumet XR, you can do so through MedWatch.
Mild side effects
Mild side effects* of Janumet and Janumet XR can include:
Most of these side effects may go away within a few days or a couple of weeks. However, if they become more severe or don't go away, talk with your doctor or pharmacist.
* This is a partial list of mild side effects from Janumet and Janumet XR. To learn about other mild side effects, talk with your doctor or pharmacist or view the prescribing information for Janumet and Janumet XR.
Serious side effects
Serious side effects from Janumet and Janumet XR aren't common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you're having a medical emergency.
Serious side effects and their symptoms can include:
- Bullous pemphigoid (a rare but possibly severe skin reaction).* Symptoms can include:
- painful blisters on certain areas of the body, such as the palms of the hands, abdomen, groin, and the soles of the feet
- redness or discoloration around the affected area
- Hypoglycemia (low blood sugar).** Symptoms can include:
- Pancreatitis (inflammation of the pancreas).* Symptoms can include:
- diarrhea, nausea, or vomiting
- Severe joint pain.* Symptoms can include:
- swelling, tenderness, and stiffness around the affected joint
- Lactic acidosis (dangerous buildup of lactic acid in your body).†
- Allergic reaction.‡
- Heart problems.‡
- Kidney issues.‡
* This side effect wasn't reported in clinical trials of Janumet and Janumet XR. It was reported after the drugs became available for use.
** The risk of low blood sugar with Janumet and Janumet XR is higher when the drugs are taken with certain other diabetes medications. For details, see the "Janumet and Janumet XR interactions" section below.
† Janumet and Janumet XR have a
‡ For more information about this side effect, see "Side effect details" below.
Side effect details
Here's some information on certain side effects this drug may cause.
Lactic acidosis
Lactic acidosis is a possible side effect of Janumet and Janumet XR. In rare cases, this side effect can be fatal. With lactic acidosis, there's a dangerous buildup of lactic acid in your body. This condition is a serious medical emergency that requires immediate treatment.
Due to this risk, Janumet and Janumet XR have a
Lactic acidosis wasn't reported as a side effect in clinical trials of Janumet and Janumet XR. However, there have been reports of lactic acidosis since metformin became available for use. (Metformin is one of the active ingredients in Janumet and Janumet XR.)
You may have a higher risk of lactic acidosis with Janumet and Janumet XR if you have certain conditions. These include kidney and liver problems. Your risk may also be higher if you drink large amounts of alcohol or if you're age 65 years or older.
Symptoms of lactic acidosis include:
If you have symptoms of lactic acidosis, stop taking Janumet and Janumet XR and call your doctor immediately. However, if your symptoms feel life threatening, you should call 911 or your local emergency number right away.
Heart problems
Heart problems are possible with Janumet and Janumet XR. This side effect wasn't reported in clinical trials of Janumet and Janumet XR. However, there have been reports of certain heart problems in studies of other dipeptidyl peptidase-4 (DPP-4) inhibitors. (Sitagliptin, one of the active ingredients in Janumet and Janumet XR, is a DPP-4 inhibitor.)
Specifically, heart failure has been reported in studies of other DPP-4 inhibitors. Symptoms of heart failure can include:
Be sure to tell your doctor if you have heart failure before starting treatment with Janumet or Janumet XR. These drugs may worsen your condition. Your doctor can advise if it's safe for you to take Janumet or Janumet XR.
Tell your doctor right away if you have symptoms of heart failure while taking Janumet or Janumet XR. They'll likely prescribe a different drug to treat your condition.
Kidney issues
Taking Janumet and Janumet XR may cause kidney issues, such as kidney failure. Kidney issues weren't reported as side effects in clinical trials of Janumet and Janumet XR. However, this side effect has been reported since the drugs became available for use.
Symptoms of kidney issues may include:
Your doctor will give you kidney function tests before you start treatment with Janumet or Janumet XR. And they'll likely check your kidney function throughout your treatment with the drug.
Keep in mind that kidney problems can raise your risk of lactic acidosis* as a side effect of Janumet or Janumet XR. (With lactic acidosis, there's a dangerous buildup of lactic acid in your body.) Due to this risk, it's important to tell your doctor if you have any symptoms of kidney issues while taking Janumet or Janumet XR.
If you develop kidney issues while taking Janumet or Janumet XR, your doctor will likely have you stop taking the drug. They may prescribe a different treatment for your condition.
* Janumet and Janumet XR have a
Allergic reactionAs with most drugs, Janumet and Janumet XR may cause allergic reaction in some people. This side effect wasn't reported in clinical trials of Janumet and Janumet XR. However, allergic reaction has been reported in people taking sitagliptin after it became available for use. (Sitagliptin is one of the active ingredients in Janumet and Janumet XR.)
Symptoms of a mild allergic reaction can include:
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:
- swelling under your skin, typically in your eyelids, lips, hands, or feet
- swelling of your tongue, mouth, or throat
- trouble breathing
Call your doctor right away if you have an allergic reaction to Janumet or Janumet XR, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you're having a medical emergency.
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